A HIV-1 Envelope (Env) vaccine that elicits broadly neutralizing antibodies (bnAbs) has remained elusive, in part due to our limited understanding of the mechanisms of bnAb induction during natural infection. Recently developed simian-human chimeric immunodeficiency viruses (SHIVs) bearing Envs from HIV-1 transmitted-founder (TF) viruses associated with bnAb induction in HIV-1 infected adult individuals now provide an experimental model to establish the mechanisms of bnAb development. HIV-1 Env bnAbs develop in ~50% of chronically-infected adults in over 3-5 years of infection, but HIV-1-infected infants and children more frequently develop bnAbs and do so faster than adults. Understanding the cellular and molecular mechanisms of infant bnAb development will facilitate design of vaccine strategies to elicit bnAbs.
Dr. Williams is investigating neonatal bnAb immunity that can be recapitulated with a vaccine, and thus is seeking a postdoctoral associate to study neonatal immunity to novel SHIVs. This candidate will be enthusiastic and willing to undertake multiple molecular biology approaches to address an area of HIV research that is understudied. Here at the Duke Human Vaccine Institute, we value collaborations, and pride ourselves in providing an excellent environment for academic and professional growth.
Education, Skills, & Experience Requirements
- Phd in biological science or related field
- MD/Phd with molecular biology research experience
- Must be able to manage multiple and rapidly changing priorities and have ability to quickly learn new skills
- Must be detail-oriented, well organized with strong communication skills and ability to work in an interactive team environment.
You will only be considered for the position after you have applied to requisition 104689 on the DHVI careers page and/or Duke Careers Website.