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Researcher in Biophysics
Stockholm University in Stockholm,
 
 
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Date Posted 01/27/2021
Category
Science-Biophysics
Employment Type Full-time
Application Deadline Open until filled
 
 
 
 
 

SciLifeLab is a national center for molecular biosciences with focus on health and environmental research. The center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience. SciLifeLab is a national resource hosted by Karolinska Institutet, KTH Royal Institute of Technology, Stockholm University and Uppsala University. The center also collaborates with several other universities.

Project description
Structural biology of supercomplexes is a young and emerging field. However, the assignment of individual subunits and cofactors is challenging, and indeed multiple mistakes have been reported. A general architecture of the membrane arm of CI curving around CIII, while CIV is in between, and its position is flexible. The mobile subunit COX7A was shown to switch between CI and CIV in the ‘tight’ and loose’ forms. Mechanistically, the structures informed that CoQ is not equally able to access its sites in CIII, suggesting its oxidation is a major rate-limiting step. The goal of the project is to isolate the mega-complex and investigate its substrate channelling.

Main responsibilities
The position involves research in the field of cryo-EM, independent use of the Titan-Krios microscope for a single-particle and tomography data collection, data processing, and manuscript preparation. Previous experience is required in the field of structural biology of bioenergetic complexes.

Qualification requirements
Researchers are appointed primarily for purposes of research and must hold a Swedish doctoral degree or an equivalent degree from another country.

Assessment criteria
In the appointment process, special attention will be given to research skills, publication track record, and previous experience in difficult problem solving.

Terms of employment
The position involves full-time employment for a maximum of two years, with the possibility of extension. Start date as per agreement.

Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact
Further information about the employment can be provided by Alexey Amunts, amunts@scilifelab.se.

Union representatives
Ingrid Lander (Saco-S), telephone: +46 708 16 26 64, saco@saco.su.se, Alejandra Pizarro Carrasco (Fackförbundet ST/Lärarförbundet), telephone: +46 8 16 34 89, alejandra@st.su.se, and seko@seko.su.se (SEKO).

Application
Apply for the position at Stockholm University's recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

Please include the following information with your application

  • Your contact details and personal data
  • Your highest degree
  • Your language skills
  • Contact details for 2–3 references

and, in addition, please include the following documents

  • Cover letter
  • CV – degrees and other completed courses, work experience and a list of publications
  • Research proposal (no more than 3 pages) describing:
    – why you are interested in the field/project described in the advertisement
    – why and how you wish to complete the project
    – what makes you suitable for the project in question
  • Copy of PhD diploma
  • Letters of recommendation (no more than 3 files)
  • Publications in support of your application (no more than 3 files).

The instructions for applicants are available at: How to apply for a position.

You are welcome to apply!

Stockholm University contributes to the development of sustainable democratic society through knowledge, enlightenment and the pursuit of truth.

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