A Post-doctoral position is available in the laboratory of Dr Douglas Feinstein for up to 2 years. The project, supported by a VA grant, focuses on the role of the enzyme LKB1 (Liver Kinase B1) in regulating neuroinflammation and neuronal damage (see Kalinin et al. GLIA 68, 600-616, 2020). Studies make use of transgenic mice with conditional knockdown of LKB1 from astrocytes and Tcells, and examine neuropathology in the EAE mouse model of Multiple Sclerosis. Tissue (brains, spinal cords) will be analyzed by immunostaining, qPCR, and western blots for changes in inflammatory gene expression, neuronal injury, and mitochondrial function. In vitro studies will use primary astrocytes and Tcells to examine effects of LKB1 deficiency on cell activation, survival, metabolism and mitochondrial function. The project will include assistance with maintenance of mouse colonies, breeding and genotyping; induction and monitoring EAE disease symptoms; isolation of RNA and proteins from tissues and cells; qPCR, RNAseq and protein analysis. Experience working with mice, preferably with EAE or a related model of neurodegenerative disease is required. Please send current cv along with names of 1 or 2 references to firstname.lastname@example.org . UIC and the Jesse Brown VA are equal opportunity employers; applications from women and minorities are encouraged.