The Mittag laboratory invites applications for a Postdoctoral Research Fellow to work on an interdisciplinary project that will involve in vitro biophysics studies of phase separation and cell biological approaches to assess function. The latter component is in collaboration with Linda Hendershot’s laboratory in the Department of Tumor Cell Biology. The project seeks to delineate the molecular mechanisms by which cancer mutations in the tumor suppressor SPOP, a ubiquitin ligase subunit, result in dysregulation of substrates. An important goal is to assess the role of phase separation for SPOP function.
The successful candidate will join a highly collaborative laboratory focused on elucidating mechanisms and function of biomolecular condensates in the Department of Structural Biology, with access to state-of-the-art instrumentation and expertise in NMR spectroscopy, X-ray crystallography, cryo-EM, single molecule techniques, and protein technology. St. Jude Children’s Research Hospital is a Fortune 100 Best Company that offers competitive salary and benefits.
Tanja Mittag, PhD
Department of Structural Biology
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
The successful candidate will take a leadership role in connecting ongoing research projects related to SPOP biology and biophysics. The candidate will receive training in biophysics and cell biological approaches, and support with career development.
Given that the project will involve interdisciplinary research at the interface of biophysics and cell biology, the successful candidate should have a Ph.D. in in vitro structural biology/biophysics or cell biology. They will add to their experimental repertoire through tight integration in the Mittag and Hendershot labs. The candidate should demonstrate an academic record of excellence, and a strong interest in the growing field of biomolecular condensates.
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