Job no: 514214
Work type: Research Faculty
Senior management: Vice President for Research
Department: Fralin Biomedical Res. Institute
Location: Roanoke Area
Categories: Research / Scientific
The laboratory of Sharon Swanger, PhD studies the molecules and mechanisms controlling synaptic transmission and circuit excitability in the thalamus as well as how thalamic physiology is dysregulated in mouse models of neurological disease. This work involves functional studies utilizing neurotransmitter receptor pharmacology, optical and electrical recordings in brain slices, and ex vivo optogenetics. We also apply biochemical and cell biological approaches including superresolution microscopy to study synaptic protein expression and localization in mouse brain tissue. Swanger lab is seeking to hire a Postdoctoral Associate. Candidate in this capacity is expected to have a solid background in electrophysiology and fluorescence imaging, and experience with mouse models of disease, small animal surgery, and biochemical approaches is highly desirable.| |Successful candidate will be expected to:|1. Record from acute brain slices isolated from mice using patchclamp electrophysiology;|2. Implement live fluorescence imaging in mouse cultured neurons and brain slices; |3. Determine cellular and molecular changes underlying hyperexcitability in mouse brain tissue;|4. Perform stereotaxic brain injections to label specific neurons for optogenetics and imaging;|5. Mentor undergraduate students in electrophysiology, fluorescence imaging, and biochemistry.
1. PhD in pharmacology, physiology, neuroscience, or a related field;|2. Proficiency in patchclamp physiology; |3. Research experience using mouse models;|4. Demonstrated experience utilizing fluorescence imaging or molecular biology methods;|5. Excellent written and oral communication skills.
1. Brain slice electrophysiology;|2. Livecell fluorescence imaging.
The successful Candidate will be required to have a criminal conviction check.
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Advertised: September 18, 2020