Department Number/Name: 0-6144-000 / Molecular Medicine
College/Division: USF Health- Morsani College of Medicine
Salary Plan: Temporary
Job Title: Postdoctoral Scholar Research
Hiring Salary/Salary Range: $50,004 - $64,008 annual
Electrophysiological characterization of APP-mediated synaptic plasticity in Alzheimer's disease mouse models .
NIH funded postdoctoral positions are available immediately to highly motivated individuals to participate in ongoing studies on Alzheimer's disease (AD). Our laboratory is focusing on the idea that Amyloid Precursor Protein (APP) could act as a receptor molecule and mediate intracellular signaling cascade under the regulation of g-secretase activity. We identified an interaction between APP intracellular domain and the heterotrimeric G-protein subunit Ga S that affects axodendritic outgrowth in AD mouse models. We established that APP-mediated signaling could have profound consequences on brain plasticity and rescue memory decline in AD mouse models . To complement our ongoing investigations, we seek to understand whether the cognitive improvement is associated with changes in regional brain plasticity that underlies a function of APP and its metabolites using electrophysiological examination of well-characterized AD mouse models.
Relevant publications :
Deyts et al., Journal of Neuroscience , 2012. doi: 10.1523/JNEUROSCI.5433-11.2012
Deyts, Thinakaran, & Parent, Trends in Pharmacological Sciences , 2016. doi: 10.1016/j.tips.2016.01.005
Deyts et al., eLife , 2016. doi: 10.7554/eLife.15645
Deyts et al., Cell Reports , 2019. doi: 10.1016/j.celrep.2019.03.087
- Successful applicants will have the opportunity to work in a dynamic environment and train with experienced molecular, cellular, developmental, and behavior neuroscientists investigating various aspects of the nervous system function and dysfunction. These positions are available for up to 3-5 years.
- Applicants must hold a Ph.D. or MD. Ph.D. in a related field from an accredited institution, and a strong background in neurobiology, molecular/cellular biology, or mouse behavior. Must meet university criteria for appointment at the rank of Postdoctoral Fellow.
- The candidate should have a keen interest in understanding complex mechanisms underlying memory formation and storage in mouse models of Alzheimer’s disease. Previous experience in synaptic physiology, cell culture system, brain expression of viral proteins, or optogenetic approach will be an asset.
This position is subject to a Level 1 criminal background check.
Job Opening Number: 25103
Posting Date: 05/07/2020- original posting date
Posting End Date: 09/26/2020 (Previous applicants need not reapply)
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