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Postdoctoral Fellow – Drug Discovery in Colorectal Cancer
Moffitt Cancer Center in the Tampa, Florida
Date Posted 09/01/2020
Employment Type Full-time
Application Deadline Open until filled

Dr. Hao Xie is a physician scientist who has clinical expertise in colorectal cancer and research in synthetic organic chemistry and translational medicine. He is starting a new laboratory focusing on drug discovery and development using novel patient-derived tumor models and phosphoproteomics in colorectal cancer. His laboratory research projects include the following: 1) design and synthesis of novel small molecules for targeted protein degradation in the form of proteolysis targeting chimera and autophagy targeting chimera; 2) evaluate the biological and molecular effects of targeted protein degradation on KRAS-mutant colorectal cancer and tumor angiogenesis in colotectal cancer. 3) preclinical evaluation of targeted protein degradation in combination with traditional kinase inhibitions.

Position Highlights:

  • Opportunity to work with a team of scientists and physicians in interdisciplinary fields of synthetic organic chemistry, cell biology, and translational research in colorectal cancer.
  • Share the motivation of a newly established laboratory for journal publications and grant applicaions.
  • Moffitt integrates excellent patient care with cutting-edge clinical and basic research. Having a cancer hospital on-site provides unique opportunities for translational research.
  • Outstanding mentorship from expert faculty with wide-ranging funded research programs
  • You will be encouraged and supported to apply for training grants.

The Ideal Candidate:

  • Completed or completing PhD training in the field of synthetic organic chemistry or chemical biology with organic chemistry experience.
  • Peer reviewed journal publication in relevant fields.


  • Independently design and perform experiements for research questions and analysize and interpret results.
  • Effective oral and written communications with PI and other team members.
  • Willing to learn new experiemental techniques and teach other trainees in the laboratory.
  • Manage laboratory supplies and maintain laboratory safety.

Credentials and Qualifications:

  • PhD or MD/PhD in synthetic organic chemistry and/or chemical biology.
  • Should have at least one first (co-first) or corresponding author publication.

You will be eligible for benefits offered to our Team Members – Medical, Dental, Vision, Paid Time Off, Retirement, Parental Leave and more. With a move to Tampa, you may be eligible for relocation allowance. Reason to relocate, aside from the sunshine, beaches and year-round outdoor recreation associated with the Gulf Coast of Florida, Tampa is a thriving metropolitan city with unique cultural attractions, low cost of living and a high quality of life. We strive for work/life balance.

If you have the vision, passion, and dedication to contribute to our mission,
then we have a place for you.

Interested applicants should send a cover letter summarizing their research training and accomplishments, scientific interests and goals, current CV with recent publications, and contact information for your PhD and/or postdoctoral adviser as a reference to Dr. Hao Xie at

Location: H. Lee Moffitt Cancer Center & Research Institute · Clinical Science Lab
Schedule: Full Time, Day Shift, variable

*Please mention to employers when applying for this job*
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