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Postdoctoral Research on tRNA Epigenetic Biology
Thomas Jefferson University in the Philadelphia, Pennsylvania
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Date Posted 04/21/2020
Science-Molecular Biology
Employment Type Full-time
Application Deadline Open until filled

Postdoctoral Research on tRNA Epigenetic Biology

Postdoctoral positions are available with Professor Ya-Ming Hou at Thomas Jefferson University, Sidney Kimmel Medical College. We focus on tRNA epigenetic changes and explore their roles in gene expression at the codon level and in response to cellular stress, which are new concepts at the cutting edge of molecular biology and central dogma. We use a synthetic biology approach with CRISPR/Cas-edited genomes to determine how modifications in tRNA impact cell fitness and human helath and disease. Our lab is intellectually stimulating and encouraging global networking. Current projects are tRNA epigenetic biology:

  1. In response to environmental stress
  2. In discovery of new bacterial physiology and antibiotic therapeutics
  3. In neurodegenerative diseases.

For more information, please see the following publications and our website:

Cell Systems, 8, 302-314 (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)

Nucleic Acids Res. 46, e37 (2018). PMID: 29361055

Nucleic Acids Res. 45, 4081-4093 (2017). PMID: 27956502

PNAS 113, 15096-15101 (2016). PMID: 27849575 (Featured in PNAS commentary)

Nat Struct Mol Biol, 10, 941-948 (2016). PMID: 27571175. (Featured in Science)

Nature Communications, 6:7226 (2015). PMID: 26009254

Chem and Biol (Cell Press) 21, 1351-1360 (2014). PMID: 25219964

Nature 510, 507-511 (2014). PMID: 24919148 (Featured in Nature News and Views)

Nat. Communications. 2:329 (2011). PMID: 21629262


Candidates with a recent Ph.D. and a passion for basic research are encouraged to apply. Experience in RNA-seq, high-throughput data analysis, fluorescence microscopy, cell culture, molecular biology, protein enzymology, nucleic acids research, and mitochondrial research is preferred.

Please send a cover letter, CV, and contact information of three references to:

Ya-Ming Hou

Professor of Biochemistry and Mol Biology

Thomas Jefferson University

233 S. 10th Street, BLSB 220

Philadelphia, PA 19107, USA

T: 215-503-4480


*Please mention to employers when applying for this job*
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